Background: Our previous work (Camilleri et al., 2019) reported negative behavioral (anxiety- and depression-like) consequences, as well as long-term physiological changes associated with drug-induced pregnancy termination at first-trimester human equivalent in a rat model.

Goal of this study: Having established the behavioral model for chemically-induced abortion and given:

  • the nature (duress) under which many induced abortions take place,
  • the clinical reports (Delgado and Davenport, 2012; Delgado et al., 2018) confirming the possibility of utilizing progesterone to reverse an abortion following the administration of mifepristone, and
  • the potential for improving the current reversal methodology,

this research seeks to build on the previously established model of drug-induced abortion to create a model of progesterone-mediated reversal of mifepristone-induced abortion (abortion-pill reversal) that will provide a pre-clinical model allowing for the investigation of various aspects associated with the procedure.